Adaptive Immunity

Prokaryotic Cells

Lesson

Topic

Essential Idea and Objective(s)

Statement(s) and Objective(s)

Activities

1	Structure		1.2.U1: Prokaryotes have a simple cell structure without compartmentalization. Outline the major differences between prokaryotic and eukaryotic cells. List the functions of the following structures of a prokaryotic cell: cell membrane, nucleoid, plasmid, cytoplasm, ribosome, cell wall, pili, capsule, flagella Define extracellular. Contrast the size of eukaryotic and prokaryotic ribosomes. 1.2.S1: Drawings of the ultrastructure of prokaryotic cells based on electron micrographs. Explain why the ultrastructure of prokaryotic cells must be based on electron micrographs. Draw the ultrastructure of E.coli from a micrograph and label the cell wall, pili, flagella, plasma membrane, cytoplasm, 70s ribosomes, and nucleoid with naked DNA.	Viewing the size difference lab 1 OR Viewing the size difference lab 2 Video showing size comparison Prokaryotic cell structure notes Prokaryotic cell structures CFU Dance - characteristics of all cells Explore E. coli images Create a model prokaryotic cell (example) Prokaryote structure review A&B: The Body Eclectic reading A&B: The Body Eclectic questions A&B: Unexplored Wilderness questions A&B: Unexplored Wilderness reading A&B: Microbiome TED talk A&B: The ultimate social network PS - Bacteria actually do have organelles and compartmentalization A&B: Largest bacterium ever discovered has an unexpectedly complex cell \| Science A&B: Classifying bacteria from This Podcast Will Kill You Episode 50 Listen between 8:00-17:30 A&B: Ocean Bacteria Reveal an Unexpected Multicellular Form
2	DNA		3.2.U1: Prokaryotes have one chromosome consisting of a circular DNA molecule. Describe the structure and function of nucleoid DNA. Define the term “naked” in relation to prokaryotic DNA. Compare the genetic material of prokaryotes and eukaryotes. 3.2.U2: Some prokaryotes also have plasmids but eukaryotes do not. Describe the structure and function of plasmid DNA.	Prokaryotic DNA notes Prokaryotic DNA review Table for comparing pro and euk data Prokaryote DNA CFU Drug resistance molecule can spread through bacterial 'communities' -- ScienceDaily Dogma-defying bacteria package DNA in unusual ways
3	Binary Fission	Single-celled organisms often reproduce asexually by binary fission. Define asexual reproduction and binary fission. Outline the steps of binary fission.	1.2.U3: Prokaryotes divide by binary fission.	Binary fission CFU Quizizz review game
4	Prokaryote Metabolism		(was explicitly part of former syllabus) 2.9.A1: Changes to the Earth’s atmosphere, oceans and rock deposition due to photosynthesis State that (some) prokaryotes, algae and plants carry out photosynthesis. Define and state evidence for the “Great Oxidation Event.”	Steven Allison: Earth's original inhabitants -- and their role in combating climate change \| TED Talk Prokaryote metabolism notes Review of prokaryote metabolism Great oxidation event notes Prokaryote metabolism CFU Reading: changes in the air Great little interview with info about change in Earth's atmosphere over time: No rain for days in the Northwest. And a primer on how Earth's atmosphere formed. \| KNKX Public Radio A&B: Ecosystem Inside readings
5	Antibiotics		6.3.U7: Antibiotics blocks processes that occur in prokaryotic cells but not in eukaryotic cells. Define antibiotic. Outline the mechanisms by which antibiotics kill bacteria. 6.3.U8: Viruses lack a metabolism and cannot therefore be treated with antibiotics. Explain why antibiotics are ineffective against viruses.	What are antibiotics reading Antibiotics notes Antibiotics and disease treatment (virtual disease sort) Antibiotics CFU A&B: This Podcast Will Kill You Episode 50 Listen between 17:30-37:40
6	Discovery of Antibiotics		6.3.A3 : Florey and Chain’s experiments to test penicillin on bacterial infections in mice. Explain methods and results of Florey and Chain’s experiments. 6.3.NOS: Risks associated with scientific research- Florey and Chain’s tests on the safety of penicillin would not be compliant with current protocol on testing. Compare allowable research risks of the past with those of the present.	Fleming notes (handwritten) Florey and Chain notes (handwritten) Discovery and testing notes Discovery google arts and culture Discovery of antibiotics CFU Article about human testing of penicillin Nuremberg Code Click on: Penicillin and Medical Drugs Penicillin movie directions (rubric) A&B: This Podcast Will Kill You Episode 50 Listen between 54:40- 1:16 A&B: Sawbones Episode 218 Listen between 23:20 - 32:00 A&B: Science Diction Serendipity Listen between 11:40 - 13:00
7	Wrap Up and Review			Kahoot review Final knowledge audit Quizlet review set 1-page summary